A visualisation applet of the Macros of the International Classification of Diseases (ICD)
ICD, ICD-10, ICD-9, ICD-8
Register here to create your own free profile and benefit from the full use of the siteNumerous studies have demonstrated that alcohol consumption by the male may be a risk factor for prostate cancer. However, the clinical significance of these studies has been questioned because of the high incidence of the disease in this population and because many of the previous studies did not adjust for potentially confounding factors, such as diet, which are associated with prostate cancer risk. Although the role of alcohol intake in the etiology of prostate cancer is unknown, it is biologically plausible. Experimental studies in animal models suggest that alcohol may act on the prostate to induce oxidative stress and thereby alter the balance of androgen metabolism, resulting in an increase in the risk of prostate cancer. Moreover, two recent prospective cohort studies reported a positive association between alcohol intake and the risk of prostate cancer. However, there is a lack of information on the role of alcohol in the etiology of prostate cancer because alcohol is consumed in a wide variety of beverage forms and the heavy drinking patterns of most studies have limited generalizability. The proposed study will be the first to rigorously examine the role of alcohol in the etiology of prostate cancer in a population-based case-control study. The study will be conducted in the state of Maryland, a low-risk area of prostate cancer. The study will include 600 incident prostate cancer cases and 600 controls matched by age, race, and geographic area. Cases and controls will be interviewed in person. Detailed information on beverage intake will be obtained using a validated food frequency questionnaire. The main objectives of this study are to examine the association of alcohol intake and risk of prostate cancer and to evaluate the impact of alcohol beverage type, amount, and duration of intake on the risk of prostate cancer. This study will be the first to examine the role of alcohol intake and the association of beverage type with the risk of prostate cancer. Findings from this study may help elucidate the role of alcohol in the etiology of prostate cancer.g. the first cupola. I could be wrong.
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